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KMID : 0525720100150040223
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Journal of Chitin and Chitosan
2010 Volume.15 No. 4 p.223 ~ p.227
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Synthesis and Characterization of Crosslinked Nano- Carrier with Thermo Responsibility
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Lee Sang-Bong
Shim Jin-Kie
Chung Suk-Jin
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Abstract
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This study is about drug delivery system (DDS) using copolymer of hydrophilic and temperature sensitive polymer. The
copolymer was maintained the particle form by crosslinking of the surface at temperature lower than lower critical solution
temperature (LCST) and it has thermo-sensitivity on changing the size of the particle above LCST. The developed copolymer is obtained or loss the amphiphilic by changing temperature then it is possible to form of the reversible particle size. Thus it can be used as a nano-carrier for drug delivery system by collected drugs. In this study, the nano-carrier can do drug delivery even under LCST.
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KEYWORD
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chitin, chitosan, drug delivery system, DDS, Lower critical solution temperature, LCST, nano-carrier
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